Human Recombinant Colony-Stimulating Factor 1 Protein (fc-CSF1)

Human Recombinant Colony-Stimulating Factor 1 Protein (fc-CSF1)


Macrophage colony-stimulating factor (M-CSF) vial of lyophilized power (Available sizes: 10µg, 50µg and 100µg).

Product Overview

Human Colony Stimulating Factor 1 (CSF1), also known as macrophage colony-stimulating factor (M-CSF), is a secreted cytokine that causes hematopoietic stem cells to differentiate into macrophages or other related cell types. This growth factor is involved in the proliferation, differentiation, and survival of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes.

CSF1 stimulates increased phagocytic and chemotactic activity of macrophages and monocytes. For hematopoietic progenitors, CSF1 interacts with membrane receptor CSR1R or M-CSF-R and modulates proliferation.

The active form of CSF1 is found extracellularly as a disulfide-linked homodimer and is thought to be produced by proteolytic cleavage of membrane-bound precursors. Upon binding of the ligand to extracellular Ig domains, CSF1R dimerizes noncovalently and autophosphorylates several tyrosine residues. This first wave of CSF1R tyrosine phosphorylation creates phosphotyrosine-binding domains to which effector proteins can bind and initiate various cellular responses.

CSF1 includes an Fc-fusion protein tag from human IgG1.

Lyophilized powder (Available sizes: 10µg, 50µg and 100µg).

Technical Specifications

Construct Detail
388-amino acid protein consisting of Glu33 to Gln181 region of CSF1
CHO stable cell line expressing fc-tagged CSF1 growing in chemically defined media with no animal component or antibiotics
10 x PBS pH 7.4
Molecular Weight
<1 EU/μg
Bioactivity (Species)
Data Pending
Data Pending

Stability & Storage

 Storage Time
Lyophilized Form
-20°C to -80°C
Until expiration date
Lyophilized Form
Room temperature
2 weeks
Reconstituted Form
-20°C to -80°C
6 months

Avoid repeated freeze-thaw cycles.

Protocols & Documentation

Download:  Product Information Sheet