Human Recombinant Brain-Derived Neurotrophic Factor I (BDNF) Protein

Human Recombinant Brain-Derived Neurotrophic Factor I (BDNF) Protein


Human brain-derived neurotrophic factor (BDNF)
Vial of lyophilized power (Available sizes: 10µg, 50µg and 100µg).

Product Overview

Human Brain-Derived Neurotrophic Factor (BDNF) is an activity-dependent neurotrophic factor that supports neurons’ differentiation1, maturation2, and survival3 and provides a neuroprotective effect under adverse conditions. BDNF stimulates and controls the growth of new neurons from neural stem cells.

BDNF binds to neurons of the central nervous and peripheral nervous systems, expressing tropomyosin receptor kinase B (TrkB) and the low-affinity nerve growth factor receptor (p75). It also activates signal transduction cascades (IRS1/2), PI3K, Akt), crucial for CREB and CBP production, that encode proteins involved in neural plasticity, stress resistance, and cell survival4.

Research areas for human recombinant BDNF are neurodegenerative disorders (e.g. Alzheimer’s, Parkinson’s and Huntington’s diseases), neuropsychiatric disorders (e.g. anxiety, depression, PTSD and schizophrenia) and neurodevelopmental disorders (e.g. autism spectrum disorder).

BDNF is synthesized in the endoplasmic reticulum (ER) as a 32-35 kDa precursor protein (pro-BDNF) that moves through the Golgi apparatus and trans-Golgi network (TGN). The terminal domain of pro-BDNF is cleaved by a distinct protein convertase enzyme to form 13.5 kDa biologically active mature BDNF (mBDNF),5.

Lyophilized powder (Available sizes: 10µg, 50µg and 100µg).

Technical Specifications

Construct Detail
120 amino acid protein consisting of the mature form of BDNF. 
Humanized pichia yeast stable cell line expressing BDNF growing in chemically defined media with no animal component or antibiotics 
10 x PBS pH 7.4 
Molecular Weight
13.5kDa (Calculated) 27.0kDa Homodimer 
<1 EU/µg 
Bioactivity Species
Data Pending
Data Pending

Stability & Storage

 Storage Time
Lyophilized Form
-20°C to -80°C
Until expiration date
Lyophilized Form
Room temperature 
2 weeks
Reconstituted Form
-20°C to -80°C
6 months

Avoid repeated freeze-thaw cycles.

Protocols & Documentation

Download: Product Information Sheet